ZID BC 011578 (ZID) | |||
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Title | Clinical management of patients on immunotherapy protocols | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Klebanoff, Christopher | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $15,439 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Digestive Diseases (2.0%) Gene Therapy (30.0%) |
Anus (2.0%) Cervical Cancer (10.0%) Lung (10.0%) Melanoma (60.0%) Penis (1.0%) Vaginal (1.0%) Sarcoma (15.0%) |
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Research Type | |||
Systemic Therapies - Discovery and Development Systemic Therapies - Clinical Applications |
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Abstract | |||
ttending-level clinical support and associate investigator in a number of therapeutic T cell protocols using naturally occurring and genetically engineered T cells to treat a range of solid and hematologic malignancies. Selected examples of current T cell therapy protocols for which I am a clinically orientated associate investigator include: 1. A Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Short-Term Cultured Tumor Infiltrating Lymphocytes Plus IL-2 Following Either a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen Alone or in Conjunction with 12Gy Total Body Irradiation (TBI) (protocol 11-C-0123). 2. A Phase II Study of Lymphodepletion followed by Autologous Tumor-Infiltrating Lymphocytes and High-Dose Aldesleukin for Human Papillomavirus-Associated Cancers (protocol 12-C-0116). 3.Phase I/II Study of Metastatic Cancer Using Lymphodepleting Conditioning Followed by Infusion of Anti-mesothelin Gene Engineered Lymphocytes (protocol 12-C-0111). 4. Phase II Study of CD62L+-derived T lymphocytes transduced with a T Cell Receptor Recognizing the NY-ESO-1 Antigen and Aldesleukin Following Lymphodepletion in Patients with NY-ESO-1 Expressing Melanoma (protocol 14-C-0058). 5. A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes (TIL) Derived from Patients with Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative Regimen (protocol 14-C-0104) |